What question did this study set out to answer?

This research aims to identify the roles of scavenger receptors SR-A and CD36 in macrophage uptake of modified low density lipoprotein (LDL).

December 1, 2002Journal of Biological ChemistryOpen Access

Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

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Authors

VKVidya KunjathoorBoston University MFMaria FebbraioUniversity of Alberta EPEugene A. PodrezCleveland Clinic Lerner College of Medicine

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Implication

Randomized trial reveals significant roles of SR-A and CD36 in modified LDL uptake in macrophages, indicating critical pathways in lipid accumulation.

Key Points

This research aims to identify the roles of scavenger receptors SR-A and CD36 in macrophage uptake of modified low density lipoprotein (LDL).
Generated mice lacking both SR-A and CD36 to assess their impact on lipid uptake.
Utilized histochemistry and gas chromatography-mass spectrometry for lipid accumulation analysis.
SR-A and CD36 account for 75-90% of degraded modified LDL uptake.
Cholesteryl ester fails to accumulate in macrophages from double null mice, indicating a lack of compensatory mechanisms.

Cite This Study

Kunjathoor et al. (2002) studied this question.

synapsesocial.com/papers/6a079913f8ea14d3ccc644a6 https://doi.org/10.1074/jbc.m209649200

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Implication

Randomized trial reveals significant roles of SR-A and CD36 in modified LDL uptake in macrophages, indicating critical pathways in lipid accumulation.

Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

Discussion

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Implication

Key Points

Cite This Study

Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

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Implication

Key Points

Cite This Study

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