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April 20, 2010Circulation

Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome

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Why the study?

Does the presence of plaque hemorrhage or intraplaque vessel formation predict future cardiovascular events in patients undergoing carotid endarterectomy?

Population

818 patients who underwent carotid endarterectomy

Comparison

Presence of specific atherosclerotic plaque… vs Absence of these specific plaque characteristics

Design

Cohort

Follow-up

mean 2.3 years

Authors

WHWillem E. HellingsDeventer ZiekenhuisWPWouter PeetersNewcastle UniversityFMFrans L. MollVascular Medicine

Discussion

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Implication

Supports histologic risk stratification after CEA; leaves open whether features should guide intensified prevention or trials.

Structured PICO

Does the presence of plaque hemorrhage or intraplaque vessel formation predict future cardiovascular events in patients undergoing carotid endarterectomy?

P
Population
818 patients who underwent carotid endarterectomy
I
Intervention
Presence of specific atherosclerotic plaque histological characteristics (plaque hemorrhage or marked intraplaque vessel formation)
C
Comparator
Absence of these specific plaque characteristics
O
Outcome
Composite of a vascular event (vascular death, nonfatal stroke, nonfatal myocardial infarction) and vascular intervention up to 3 yearscomposite

Histological features of carotid plaques, specifically hemorrhage and increased vessel formation, are independent predictors of future cardiovascular events in patients undergoing carotid endarterectomy.

Cite This Study

Hellings et al. (2010) studied this question.

synapsesocial.com/papers/6a079994f8ea14d3ccc644cahttps://doi.org/10.1161/circulationaha.109.887497
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Also Consider

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  1. 1The pathophysiology of acute coronary syndromes2000 · 619 citations
  2. 2Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events2006 · 754 citations
  3. 3Plaque Rupture in Humans and Mice2007 · 253 citations
  4. 4Hypothesis: Vasa Vasorum and Neovascularization of Human Coronary Arteries1984 · 854 citations
  5. 5Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly1997 · 1,753 citations