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February 1, 1996Circulation

Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction

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Why the study?

Does smoking carry a different risk of myocardial infarction in middle-aged women compared to men?

Population

11,843 men and women aged 35 to 52 years at entry

Comparison

Current smoking vs Never-smokers

Design

Cohort

Follow-up

12 years

Key result

Current smoking was a stronger risk factor for myocardial infarction in middle-aged women (RR 3.3; 95% CI 2.1-5.1) than in men (RR 1.9; 95% CI 1.6-2.3).

Authors

INInger NjølstadEAEgil ArnesenPLPer G. Lund‐Larsen

Discussion

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Member takes

Overview

Suggests greater MI vulnerability to smoking in middle-aged women; hypothesis-generating and requires prospective confirmation before sex-specific guidance.

Structured PICO

Does smoking carry a different risk of myocardial infarction in middle-aged women compared to men?

P
Population
11,843 men and women aged 35 to 52 years at entry
I
Intervention
Current smoking (including heavy smoking of ≥20 cigarettes per day)
C
Comparator
Never-smokers
O
Outcome
First myocardial infarctionhard clinical

Smoking is a significantly stronger risk factor for myocardial infarction in middle-aged women compared to men, particularly among those under 45 years of age.

Cite This Study

Njølstad et al. (1996) studied this question. Current smoking was a stronger risk factor for myocardial infarction in middle-aged women (RR 3.3; 95% CI 2.1-5.1) than in men (RR 1.9; 95% CI 1.6-2.3).

synapsesocial.com/papers/6a07a2b25ca7144909c64b3ahttps://doi.org/10.1161/01.cir.93.3.450
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RISK FACTORS FOR FATAL HEART ATTACK IN YOUNG WOMEN1981 · 24 citations
  2. 2Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men: The Caerphilly and Speedwell Collaborative Heart Disease Studies1992 · 210 citations
  3. 3Total and high density lipoprotein cholesterol in the serum and risk of mortality: evidence of a threshold effect.1985 · 175 citations
  4. 4Patterns of coronary heart disease morbidity and mortality in the sexes: A 26-year follow-up of the Framingham population1986 · 1,740 citations
  5. 5LIPOPROTEINS AS MEDIATORS FOR THE EFFECTS OF ALCOHOL CONSUMPTION AND CIGARETTE SMOKING ON CARDIOVASCULAR MORTALITY: RESULTS FROM THE LIPID RESEARCH CLINICS FOLLOW-UP STUDY1987 · 287 citations