Key result
Septal ablation reverses the Anrep fingerprint of enhanced contractility and prolonged ejection time in HOCM.
Why the study?
The mechanistic origin of the Anrep effect remains undefined, prompting investigation into whether relaxed myosin state transitions underlie this phenomenon and present a clinical fingerprint in pathological states.
Does septal myocardial ablation reverse the echocardiographic fingerprint of the Anrep effect in patients with hypertrophic obstructive cardiomyopathy?
Observational (n=12)
Does septal myocardial ablation reverse the echocardiographic fingerprint of the Anrep effect in patients with hypertrophic obstructive cardiomyopathy?
The Anrep effect may be driven by a shift of myosin from the super-relaxed to the disordered-relaxed state, a phenomenon that manifests clinically as hypercontractility in hypertrophic cardiomyopathy and reverses following septal myocardial ablation.
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Hypothesis-generating for myosin modulation in HOCM; leaves open confirmation in larger prospective studies.
Sequeira et al. (2024) conducted an observational in Hypertrophic obstructive cardiomyopathy (n=12). Septal myocardial ablation vs. Pre-procedure baseline was evaluated on Echocardiographic pressure-volume measurements (contractility and systolic ejection time). Septal myocardial ablation reversed the clinical Anrep fingerprint of enhanced contractility and prolonged systolic ejection time in 12 patients with hypertrophic obstructive cardiomyopathy.
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