Key result
Left ventricular chamber dilatation and systolic dysfunction developed in 14% of hypertrophic cardiomyopathy patients over 10.3 years and was associated with significantly worse event-free survival (P<0.05).
Why the study?
What is the incidence and prognosis of left ventricular chamber dilatation in patients with hypertrophic cardiomyopathy?
Population
139 patients with hypertrophic cardiomyopathy
Design
Cohort
Follow-up
10.3 (SD 6) years
Authors
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LV dilatation signals higher-risk HCM subset for closer surveillance; leaves open whether targeted interventions alter progression.
Cohort (n=139)
What is the incidence and prognosis of left ventricular chamber dilatation in patients with hypertrophic cardiomyopathy?
Absolute Event Rate: 14% vs 86%
In patients with hypertrophic cardiomyopathy, left ventricular chamber dilatation occurs in about 1.5% of patients per year and is associated with worse event-free survival and quality of life.
Seiler et al. (1995) conducted a cohort in Hypertrophic cardiomyopathy (n=139). Left ventricular chamber dilatation and systolic dysfunction vs. Stable left ventricular chamber size and systolic function was evaluated on Incidence of left ventricular chamber dilatation and systolic dysfunction. Left ventricular chamber dilatation and systolic dysfunction developed in 14% of hypertrophic cardiomyopathy patients over 10.3 years and was associated with significantly worse event-free survival (P<0.05).
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