Key result
Living myocardial slices in biomimetic chambers provide an accurate human electrophysiological model for arrhythmia research.
Why the study?
Living myocardial slices represent a comprehensive model for arrhythmia research, but their potential using biomimetic cultivation chambers and electrophysiological techniques needed to be reviewed.
Living myocardial slices cultured in biomimetic electromechanical chambers offer a promising comprehensive model for advancing cardiac arrhythmia research and developing novel therapeutic options.
May advance preclinical arrhythmia modeling; leaves open clinical translation and therapeutic impact.
Living myocardial slices (LMS) are ultrathin (150-400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options.
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Amesz et al. (2023) conducted a review in Cardiac arrhythmias. Living myocardial slices (LMS) was evaluated. Living myocardial slices cultured in biomimetic electromechanical chambers provide a valid in-vitro model with high human electrophysiological mimicry for advancing cardiac arrhythmia research.
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