January 17, 2013European Journal of Heart Failure
The Emerging Issue of Cardiac Dysfunction Induced by Antineoplastic Angiogenesis Inhibitors
Key result
Antiangiogenic drugs, particularly VEGF inhibitors, can produce a broad spectrum of cardiovascular side effects including left ventricular dysfunction, requiring careful assessment and management.
Population
Cancer patients receiving antineoplastic angiogenesis inhibitors (VEGF inhibitors)
Design
Review
Authors
Discussion
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Implication
Supports monitoring for LV dysfunction with VEGF inhibitors in cancer patients; leaves open optimal strategies pending prospective data.
Key Points
- This review aims to explore the cardiac dysfunction linked to antineoplastic angiogenesis inhibitors, particularly focusing on their mechanisms and associated cardiotoxic effects.
- Reviewed literature on cardiotoxicity from antiangiogenic drugs, particularly VEGF inhibitors.
- Analyzed mechanisms and pathophysiology of cardiac dysfunction.
- Discussed assessment and management strategies based on recent guidelines.
- Cardiotoxic effects from antiangiogenic drugs include left ventricular dysfunction, affecting myocardial function.
- Increased recognition of various toxicities with the rise of targeted therapies in cancer treatments.
- Vascular endothelial growth factor inhibitors have been associated with significant cardiovascular side effects.
Structured PICO
P
Population
Cancer patients receiving antineoplastic angiogenesis inhibitors (VEGF inhibitors)
I
Intervention
Antineoplastic angiogenesis inhibitors (VEGF inhibitors)
O
Outcome
Left ventricular dysfunction and cardiovascular side effects
VEGF inhibitors are associated with significant cardiotoxic effects, particularly left ventricular dysfunction, necessitating careful assessment and management based on heart failure guidelines.
Cite This Study
Tocchetti et al. (2013) conducted a review in Cardiac dysfunction induced by antineoplastic angiogenesis inhibitors. Antineoplastic angiogenesis inhibitors (VEGF inhibitors) was evaluated. Antiangiogenic drugs, particularly VEGF inhibitors, can produce a broad spectrum of cardiovascular side effects including left ventricular dysfunction, requiring careful assessment and management.