Key result
Frailty is linked to a ~42% lower likelihood of OAC prescription in older hospitalized AF patients.
Why the study?
Evidence regarding the impact of frailty on oral anticoagulant prescription in older individuals with atrial fibrillation is conflicting.
Does frailty reduce the prescription of oral anticoagulants in older hospitalized patients with atrial fibrillation?
Population
685 hospitalized patients aged ≥65 with AF across six hospitals in Australia
Comparison
Frailty (Frailty Index ≥0.25) vs non-frail
Design
Multicentre retrospective observational study
Authors
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Supports individualized OAC decisions incorporating frailty in older AF inpatients; extends conflicting prior data but remains hypothesis-generating.
Cohort (n=685)
Yes
Does frailty reduce the prescription of oral anticoagulants in older hospitalized patients with atrial fibrillation?
Effect estimate: OR 0.58 (95% CI 0.39-0.86)
Absolute Event Rate: 67.9% vs 81.4%
p-value: p=<0.001
In older hospitalized patients with atrial fibrillation, frailty is highly prevalent and independently associated with a reduced likelihood of oral anticoagulant prescription and an increased likelihood of rate-control medication prescription.
Nguyen et al. (2024) conducted a cohort in Atrial fibrillation (n=685). Frailty vs. Non-frail was evaluated on Prescription of oral anticoagulants (OAC) during hospitalisation (OR 0.58, 95% CI 0.39-0.86, p=<0.001). Frailty was associated with a significantly reduced likelihood of oral anticoagulant prescription during hospital admission in older patients with atrial fibrillation (adjusted OR 0.58).
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