Key result
Acute and chronic captopril therapy improved the hemodynamic response to tilt and normalized efferent sympathetic activity in severe heart failure, though 5 patients developed orthostatic hypotension.
Why the study?
Does acute and chronic converting-enzyme inhibition with captopril improve the hemodynamic, hormonal, and baroreceptor responses to tilt in patients with severe chronic congestive heart failure?
Observational (n=12)
Does acute and chronic converting-enzyme inhibition with captopril improve the hemodynamic, hormonal, and baroreceptor responses to tilt in patients with severe chronic congestive heart failure?
Captopril therapy in severe heart failure improves sympathetic responsiveness but can cause orthostatic hypotension during chronic use due to an impaired reflex increase in systemic vascular resistance.
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Captopril may improve tilt hemodynamics in severe HF but risks orthostatic hypotension; leaves open net benefit pending randomized confirmation.
Cody et al. (1982) conducted an observational in Severe chronic congestive heart failure (n=12). Captopril vs. Baseline (control tilt) was evaluated on Hemodynamic and hormonal response to tilt and baroreceptor response. Acute and chronic captopril therapy improved the hemodynamic response to tilt and normalized efferent sympathetic activity in severe heart failure, though 5 patients developed orthostatic hypotension.
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