Key result
Adult women face higher TdP and SCD risk in LQTS, while Brugada syndrome predominantly affects men.
Why the study?
Despite increasing recognition of sex-related differences in cardiac channelopathies, essential knowledge gaps remain in the mechanistic understanding of these disparities.
Sex-related differences significantly impact the prevalence, clinical presentation, and outcomes of cardiac channelopathies, highlighting the need for individualized care and further mechanistic research.
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Supports sex-specific risk assessment in long-QT syndrome and Brugada syndrome; leaves open mechanistic and therapeutic targets for prospective study.
Asatryan et al. (2021) conducted a review in Cardiac channelopathies. Adult women carry a greater risk for Torsades de pointes and sudden cardiac death in congenital long-QT syndrome, whereas Brugada syndrome predominantly affects adult men with higher arrhythmic risk.
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