Key result
High baseline serum C-reactive protein (≥3.0 mg/L) was associated with a significantly higher risk of 4-year all-cause mortality in chronic hemodialysis patients compared to levels <1.0 mg/L (HR 2.786).
Why the study?
Is serum CRP, serum albumin, or pulse wave velocity a better predictor of 4-year mortality in chronic hemodialysis patients?
Cohort (n=186)
No
Is serum CRP, serum albumin, or pulse wave velocity a better predictor of 4-year mortality in chronic hemodialysis patients?
Effect estimate: HR 2.786 (95% CI 1.045-7.429)
p-value: p=0.0406
Serum CRP levels are a better predictor of long-term mortality than serum albumin or pulse wave velocity in patients on maintenance hemodialysis.
AIM: Although serum albumin and C-reactive protein (CRP) levels and pulse wave velocity (PWV) are known to be associated with the clinical outcome of hemodialysis (HD) patients, it is unknown which of these parameters are more predictive of the long-term mortality of such patients. METHODS: We measured biochemical parameters, including serum albumin and CRP, and the PWV of 202 patients on maintenance HD therapy and followed their course for 4 years, and 186 of the patients were enrolled in the current study analyses. We divided the 186 patients into three tertiles according to their serum albumin and CRP levels and PWV values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality. RESULTS: Twenty-three (12.4%) patients died during the follow-up period, and the serum albumin of the group that died was significantly lower than in the group that survived, but the CRP levels and PWV were significantly higher in the group that died. The results of Kaplan-Meier analyses revealed a significantly higher risk of all-cause mortality in HD patients with higher CRP based on the results of Cox proportional hazards analyses; however, the serum albumin and PWV values were not associated with all-cause mortality. CONCLUSION: The results of this study suggest that serum CRP levels are a better mortality predictor than serum albumin or PWV values of chronic HD patients.
No takes yet. Share an insight, caveat, or question.
Amemiya et al. (2011) conducted a cohort in Chronic hemodialysis (n=186). High serum C-reactive protein (top tertile, ≥3.0 mg/L) vs. Low serum C-reactive protein (bottom tertile, <1.0 mg/L) was evaluated on All-cause mortality (HR 2.786, 95% CI 1.045-7.429, p=0.0406). High baseline serum C-reactive protein (≥3.0 mg/L) was associated with a significantly higher risk of 4-year all-cause mortality in chronic hemodialysis patients compared to levels <1.0 mg/L (HR 2.786).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: