What question did this study set out to answer?

This study aimed to evaluate the prevalence of left ventricular dysfunction in children with frequent premature ventricular contractions (PVCs).

June 14, 2019Annals of Noninvasive ElectrocardiologyOpen Access

High burden of premature ventricular contractions in structurally normal hearts: To worry or not in pediatric patients?

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Why the study?

Data are scarce on the significance of a high percentage of PVCs in healthy children, including their impact on LV function and risk of ventricular arrhythmias.

Population

134 children aged 6 months-21 years with PVCs on 24-hr Holter monitoring

Design

Single-center retrospective review

Follow-up

Median 2.8 years

Authors

NSNandita SharmaIndian Institute of Technology Kharagpur DCDaniel CortezElectrophysiology JIJason R. ImundoPediatric Cardiology

Discussion

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Implication

Supports observation without intervention for frequent PVCs in children with normal hearts; extends natural history data but remains hypothesis-generating.

Key Points

This study aimed to evaluate the prevalence of left ventricular dysfunction in children with frequent premature ventricular contractions (PVCs).
Single-center retrospective review
Included children aged 6 months to 21 years with PVCs from 24-hour Holter monitoring
Categorized PVC burden into levels (>10%, 10%-20%, >20%)
A total of 134 children were included, with 65 showing more than 10% PVCs and 31 more than 20%.
Median PVC burden was 8.7% with a follow-up median duration of 2.8 years.
During follow-up, PVC burden decreased by 67% in those without intervention, indicating a trend towards spontaneous resolution.

Structured PICO

Population

134 children aged 6 months-21 years with structurally normal hearts and frequent PVCs noted on 24-hr Holter monitoring, median age 10.5 years, 54.5% male.

Outcome

Prevalence of LV systolic dysfunction (PVC-induced cardiomyopathy) and natural history of PVC burdensurrogate

Frequent premature ventricular contractions in children with structurally normal hearts have a benign natural history with a tendency for spontaneous resolution and no observed mortality.

Cite This Study

Sharma et al. (2019) studied this question.

synapsesocial.com/papers/6a07b5e67ba19a189e06b332 https://doi.org/10.1111/anec.12663

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Implication

Supports observation without intervention for frequent PVCs in children with normal hearts; extends natural history data but remains hypothesis-generating.

High burden of premature ventricular contractions in structurally normal hearts: To worry or not in pediatric patients?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

High burden of premature ventricular contractions in structurally normal hearts: To worry or not in pediatric patients?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider