What question did this study set out to answer?

This research aims to assess the long-term consequences of premature ventricular complexes (PVCs) in adults without evident heart disease.

July 10, 2012Heart

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

View Full Paper

Ask AI

Bookmark

Why the study?

Does the presence of premature ventricular complexes increase the risk of mortality or ischaemic heart disease in adults without clinically apparent heart disease?

Key Points

This research aims to assess the long-term consequences of premature ventricular complexes (PVCs) in adults without evident heart disease.
Conducted a meta-analysis and systematic review of studies on adults without heart disease.
Analyzed outcomes of all-cause mortality, cardiovascular mortality, sudden cardiac death, and development of ischemic heart disease.
Used random effects models and meta-regression to evaluate predictors of events.
Eight studies were included, showing a pooled odds ratio (OR) of 1.72 (95% CI 1.28 to 2.31) for cardiovascular events in patients with PVCs.
Mean sample age, diabetes, and hypertension were identified as significant predictors of cardiovascular events.
Increased events were noted only in studies with 100% male populations.

Structured PICO

Does the presence of premature ventricular complexes increase the risk of mortality or ischaemic heart disease in adults without clinically apparent heart disease?

Population

Adults without clinically apparent heart disease (pooled from 8 controlled studies)

Intervention

Presence of premature ventricular complexes (PVCs) on ECG recording

Comparator

Absence of premature ventricular complexes (PVCs)

Outcome

Composite of all-cause mortality, cardiovascular mortality, sudden cardiac death or development of ischaemic heart diseasehard clinical

In adults without clinically apparent heart disease, PVCs are associated with increased adverse cardiovascular outcomes, though this risk appears driven by older patients with higher cardiovascular risk who may have undiagnosed structural heart disease.

Limitations

Most studies did not use advanced tests (echocardiogram or stress test) to rule out structural heart disease
Possible inadvertent inclusion of patients with occult structural heart disease

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Incidental PVCs may prompt cardiovascular risk assessment in apparently healthy adults; leaves open causality versus undetected structural disease.

Cite This Study

Lee et al. (2012) studied this question.

synapsesocial.com/papers/6a07b5e67ba19a189e06b337 https://doi.org/10.1136/heartjnl-2012-302005

Topics

Women and heart disease

View Full Paper

Ask AI

Bookmark

Implication

Incidental PVCs may prompt cardiovascular risk assessment in apparently healthy adults; leaves open causality versus undetected structural disease.

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider