Key result
The presence of both hot flashes and night sweats in postmenopausal women was associated with a higher risk of CIMT > 0.80 mm (adjusted OR 3.2; 95% CI 2.3-4.5; P<0.001) and lower BMD.
Why the study?
Are vasomotor symptoms associated with higher CIMT and lower BMD in postmenopausal women?
Cross-Sectional (n=204)
Are vasomotor symptoms associated with higher CIMT and lower BMD in postmenopausal women?
Effect estimate: OR 3.2 (95% CI 2.3-4.5)
p-value: p=<0.001
Vasomotor symptoms in postmenopausal women are associated with increased subclinical atherosclerosis (higher CIMT) and lower bone mineral density.
Should not yet change practice in postmenopausal women; leaves open whether vasomotor symptoms predict incident CVD or fractures.
OBJECTIVE: To determine whether postmenopausal women with vasomotor symptoms have a lower bone mineral density (BMD) and a higher carotid intima-media thickness (CIMT) than those without vasomotor symptoms. METHODS: Postmenopausal women with (n=87) or without (n=117) vasomotor symptoms who did not receive hormone therapy were included. The CIMT and BMD were determined and the relationship with vasomotor symptoms evaluated. RESULTS: The presence of both hot flashes and night sweats was associated with a CIMT of more than 0.80 mm after adjusting for age, time since menopause, and body mass index (adjusted odds ratio 3.2; 95% confidence interval [CI], 2.3-4.5; P<0.001). The adjusted odds ratio for a CIMT higher than 0.80 mm in women with night sweats was 3.6 (95% CI 1.5-8.9; P=0.006); the adjusted odds ratio in women with hot flashes was 23.1 (95% CI 9.1-58.4; P<0.001). The mean CIMT was 0.65±0.08 mm in the asymptomatic group and 0.81±0.06 mm in the symptomatic group (P<0.001). The mean lumbar (L1, L2, and L3) and total hip BMD values were lower in the symptomatic group (P<0.05). CONCLUSION: Hot flashes and night sweats in postmenopausal women are associated with a higher CIMT and a lower BMD.
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Özkaya et al. (2011) conducted a cross-sectional in Postmenopausal women (n=204). Vasomotor symptoms (hot flashes and night sweats) vs. No vasomotor symptoms was evaluated on Carotid intima-media thickness (CIMT) > 0.80 mm (OR 3.2, 95% CI 2.3-4.5, p=<0.001). The presence of both hot flashes and night sweats in postmenopausal women was associated with a higher risk of CIMT > 0.80 mm (adjusted OR 3.2; 95% CI 2.3-4.5; P<0.001) and lower BMD.
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