Oxidative stress and inflammation serve as central mediators of adverse atrial structural and electrical remodeling that lead to the onset and maintenance of atrial fibrillation in the diabetic heart.
Oxidative stress and inflammation serve as central mechanistic links between obesity, diabetes, and atrial fibrillation, representing potential therapeutic targets to improve atrial excitability.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.
Karam et al. (2017) conducted a review in Atrial fibrillation in obesity and diabetes. Oxidative stress and inflammation serve as central mediators of adverse atrial structural and electrical remodeling that lead to the onset and maintenance of atrial fibrillation in the diabetic heart.