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September 17, 2025The Annual Review of Pharmacology and Toxicology

Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation

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Authors

LSLisa StollSt. Luke's University Health NetworkEHEun‐Hee HaEwha Womans UniversityJLJames C. LoCornell University

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Overview

This review discusses the relationship between metabolic disease and atrial fibrillation, highlighting inflammation and novel therapeutic strategies.

Key Points

  • Atrial fibrillation is linked to metabolic disease, particularly obesity and type 2 diabetes, suggesting a need for targeted treatments.
  • Chronic inflammation plays a significant role in the development of atrial fibrillation, as evidenced by various observational and clinical studies.
  • Recent advances in research reveal mechanisms associated with atrial fibrillation that intertwine with metabolic factors and inflammation.
  • Understanding these mechanisms may enhance therapeutic approaches, including the emerging role of calcitonin in managing atrial fibrillation.

Cite This Study

Stoll et al. (2025) studied this question.

synapsesocial.com/papers/68d4596631b076d99fa5bfd1https://doi.org/10.1146/annurev-pharmtox-062124-025403
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Considerations in Atrial Fibrillation　― Mechanistic Insights and Therapeutic Opportunities ―2017 · 92 citations
  2. 2Atrial fibrillation and metabolic syndrome: an updated review of mechanisms, risk factors, and therapeutic strategies2026
  3. 3The role of inflammation, fibrosis, and metabolic stress in the formation and maintenance of atrial fibrillation2025
  4. 4Metabolic Remodeling and Mitochondrial Stress in Atrial Fibrillation: Mechanisms and Translational Targets2025 · 5 citations
  5. 5Inflammation Fueling Atrial Fibrillation Substrate: Seeking Ways to “Cool” the Heart2014 · 11 citations