Key result
A single 20 mg dose of propranolol improved peak oxygen consumption in patients with POTS compared to placebo (27.6 vs 24.5 mL/min/kg; p=0.024).
Why the study?
Does a single low dose of propranolol improve peak oxygen consumption in patients with postural tachycardia syndrome?
RCT (n=18)
Double-blind
Does a single low dose of propranolol improve peak oxygen consumption in patients with postural tachycardia syndrome?
Absolute Event Rate: 27.6% vs 24.5%
p-value: p=0.024
A single 20 mg dose of propranolol modestly improves exercise capacity and heart rate control in patients with postural tachycardia syndrome.
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May improve exercise tolerance with single-dose propranolol in POTS; extends prior heart-rate data to objective fitness measures.
Arnold et al. (2013) conducted an RCT in Postural tachycardia syndrome (POTS) (n=18). Propranolol vs. Placebo was evaluated on Peak oxygen consumption (VO2max) (p=0.024). A single 20 mg dose of propranolol improved peak oxygen consumption in patients with POTS compared to placebo (27.6 vs 24.5 mL/min/kg; p=0.024).
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