Population
Muscle tissue and HeLa cells (preclinical models)
Comparison
Recombinant adeno-associated viral vectors and… vs Plasmid-based vectors without the specific viral…
Design
Preclinical
Follow-up
80 days postinfection
Authors
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ITR configurations may boost rAAV vector durability in preclinical models; leaves open translation to sustained human gene therapy.
Specific structural characteristics of AAV circular intermediates, notably head-to-tail ITR configurations, explain the long-term episomal persistence and transgene expression of rAAV vectors in muscle tissue.
Duan et al. (1998) studied this question.
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