Why the study?
Does cardiac-specific overexpression of TNF-alpha cause oxidative stress and contractile dysfunction in the mouse diaphragm?
Population
Transgenic mice with cardiac-restricted overexpression of tumor necrosis factor-alpha exhibiting a heart…
Comparison
Cardiac-specific overexpression of TNF-alpha vs Wild-type littermate controls
Design
Preclinical
Authors
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Cardiac TNF-α overexpression may impair diaphragm function via oxidants in HF models; hypothesis-generating for antioxidant therapies before clinical translation.
Does cardiac-specific overexpression of TNF-alpha cause oxidative stress and contractile dysfunction in the mouse diaphragm?
In a mouse model of heart failure, elevated circulating TNF-alpha from the heart causes diaphragm contractile dysfunction via oxidative stress, which is partially reversible with antioxidants.
Li et al. (2000) studied this question.