What is the clinical evidence from this study?

Study design: Other. Population: Cardiac Failure (n=4). Intervention: Transgenic expression of murine TNF-alpha. Primary outcome: Cardiac function, pathology, and survival.

What question did this study set out to answer?

This study aims to understand the effects of TNF-alpha production by cardiac myocytes on heart function in transgenic mice.

April 14, 1998CirculationOpen Access

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

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Key result

Tissue-specific production of TNF-alpha by cardiac myocytes in transgenic mice caused severe cardiac disease, including biventricular dilatation, depressed ejection fractions, and premature death.

Population

Transgenic mice in which expression of a murine TNF-alpha coding sequence was driven by the murine…

Design

Preclinical

Authors

DBDebora D. BryantBaylor College of Medicine LBLisa BeckerCarl von Ossietzky Universität Oldenburg JRJames A. RichardsonUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Hypothesis-generating for TNF-alpha as HF driver; leaves open whether cytokine blockade alters human outcomes.

Key Points

This study aims to understand the effects of TNF-alpha production by cardiac myocytes on heart function in transgenic mice.
Developed transgenic mice expressing murine TNF-alpha driven by the alpha-myosin heavy chain promoter.
Assessed cardiac function through ECG-gated MRI.
Conducted pathological examinations on affected animals.
Transgenic mice exhibited severe cardiac dysfunction with biventricular dilatation and impaired ejection fractions.
All transgenic mice experienced premature death with significant findings of myocyte apoptosis and myocarditis.
Pathological analysis revealed biventricular fibrosis, atrial thrombosis, and notable cardiac structural abnormalities.

Structured PICO

Population

Transgenic mice in which expression of a murine TNF-alpha coding sequence was driven by the murine alpha-myosin heavy chain promoter (n=4 transgenic founders)

Intervention

Myocardial expression of Tumor Necrosis Factor-alpha (TNF-alpha)

Outcome

Development of cardiac illness, cardiac function (by ECG-gated MRI), and pathological changes

Tissue-specific production of TNF-alpha by cardiac myocytes is sufficient to cause severe cardiac disease, supporting a causal role for this cytokine in the pathogenesis of human heart failure.

Cite This Study

Bryant et al. (1998) studied Cardiac Failure (n=4). Transgenic expression of murine TNF-alpha was evaluated on Cardiac function, pathology, and survival. Tissue-specific production of TNF-alpha by cardiac myocytes in transgenic mice caused severe cardiac disease, including biventricular dilatation, depressed ejection fractions, and premature death.

synapsesocial.com/papers/6a0a0fc141a1eeaa0645addb https://doi.org/10.1161/01.cir.97.14.1375

Topics

Heart failure HFrEF treatment Cardiomyopathy Cardiac amyloidosis

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Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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