Why the study?
What is the incidence and mechanism of statin-associated myotoxicity in patients taking statins?
What is the incidence and mechanism of statin-associated myotoxicity in patients taking statins?
Statin-associated myotoxicity ranges from common mild myalgia (5-7%) to extremely rare rhabdomyolysis, with mechanisms likely involving multiple cellular factors.
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May inform statin risk discussions; leaves open mechanisms and contemporary incidence estimates.
Arora et al. (2006) studied this question.
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