We describe an optoacoustic imaging technique based on time-resolved measurements of laser-induced thermoelastic expansion. Tomographic images of tissue phantoms are formed using such measurements made at several locations following irradiation with a Q-switched Nd:YAG (λ=1064nm) laser pulse. Our system is based on a modified Mach–Zehnder interferometer that measures surface displacement with a temporal resolution of 4ns and a displacement sensitivity of 0.3nm. Images formed from data sets acquired from several highly scattering tissue phantoms provide better than 200μm resolution and show great promise for high-resolution noninvasive imaging of heterogeneous tissues at depths approaching 1cm.
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Carp et al. (2004) studied this question.
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