Key result
Cirrhosis severity is linked to higher pro-BNP and prolonged QTc, supporting a cardiomyopathy association.
Why the study?
The study investigated the association of pro-BNP, troponin-I, ECG, and echocardiography during the diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients.
Are pro-BNP, troponin-I, ECG, and ECHO parameters associated with cirrhotic cardiomyopathy in patients with cirrhosis?
Cross-Sectional (n=90)
Are pro-BNP, troponin-I, ECG, and ECHO parameters associated with cirrhotic cardiomyopathy in patients with cirrhosis?
Pro-BNP levels and QTc prolongation correlate with the severity of cirrhosis, supporting their utility as markers for cirrhotic cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May support noninvasive detection of cirrhotic cardiomyopathy severity; leaves open prognostic value and need for prospective validation.
INTRODUCTION: We investigated association of pro-BNP, troponin-I, electrocardiography (ECG) and echocardiography (ECHO) during diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients. MATERIALS AND METHODS: Patients were divided into three groups as; compensated cirrhotic patients (group 1, n= 30), decompensated cirrhotic (group 2, n = 30) and control group (group 3, n = 30). ECHO, and ECG were performed, and troponin-I and levels of pro-BNP were analyzed. RESULTS: Average age of group 1 was 46.36 ± 16 years (range 19-86), 60% were female; group 2 was 57.03 ± 13.54 years (range 22-89), 56% female; and group 3 was 49.13 ± 0.95 years (range 18-80), 56% female. A significant increase in QTc was detected in compensated cirrhotic patients compared to the control group (p <0.05). Pro-BNP levels were significantly higher (p <0.05) in the compensated cirrhotic group compared to the control group. The levels of pro-BNP were also significantly higher in the decompensated cirrhotic group compared compensated cirrhosis group and control group (p <0.001). CONCLUSION: The increase of pro-BNP levels with severity of the disease in cirrhotic patients and the prolongation of QTc interval supports an association between these factors with cardiomyopathy. HOW TO CITE THIS ARTICLE: Sezgin B, Cindoglu C, et al. Association of Cirrhosis and Cardiomyopathy. Euroasian J Hepatogastroenterol 2019;9(1):23-26.
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UYANIKOĞLU et al. (2019) conducted a cross-sectional in Cirrhosis (n=90). Cirrhosis (compensated and decompensated) vs. Control group was evaluated on pro-BNP levels and QTc interval (p=<0.001). Cirrhosis severity was associated with significantly higher pro-BNP levels (p<0.001 for decompensated vs controls) and prolonged QTc intervals, supporting an association with cardiomyopathy.
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