Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid

S. T. Raterman; Johannes W. Von den Hoff; Sietske Dijkstra; Cheyenne De Vriend; Tim Te Morsche; Sanne Broekman; Jan Zethof; Erik de Vrieze; Frank A. D. T. G. Wagener; Juriaan R. Metz

doi:10.3389/fcell.2023.1143844

March 13, 2023Frontiers in Cell and Developmental BiologyOpen Access

Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid

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Key Points

The study aims to explore the role of the foxe1 gene in craniofacial skeleton and thyroid development in zebrafish.
Utilized zebrafish models with disrupted foxe1 gene.
Analyzed differential signaling pathways related to osteogenic and chondrogenic genes.
Examined the impact of foxe1 mutation on skeletal and thyroid development.
Foxe1 disruption significantly affected development of the craniofacial skeleton and thyroid.
Notable differential signaling was observed in osteogenic and chondrogenic genes post-mutation.
The findings underscore the evolutionary conservation of foxe1 functions in vertebrate development.

Implication

Investigates the role of Foxe1 in craniofacial and thyroid development in zebrafish, suggesting significant conservation of function.

Abstract

Taken together, our findings highlight the conserved role of Foxe1 in skeletal development and thyroidogenesis, and show differential signaling of osteogenic and chondrogenic genes related to foxe1 mutation.

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Cite This Study

Raterman et al. (2023) studied this question.

synapsesocial.com/papers/6a07ecef7ad161a3abfe09c5 https://doi.org/10.3389/fcell.2023.1143844

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Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid

Key Points

Implication

Abstract

Discussion

Cite This Study

Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid

Key Points

Implication

Abstract

Discussion

Cite This Study

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