Key result
Multi-omics analysis of endurance genetics helps guide personalized training and injury prevention.
Why the study?
A multi-omics approach is needed to better understand the complex interactions between genetic polymorphisms and physiological traits, and to address issues like small sample sizes and heterogeneity in heritability estimates.
Understanding the mechanistic relationship between genetics and endurance performance can lead to personalized training strategies, injury prevention, and improved health outcomes.
Answers are grounded in this paper and cite their sources.
Not ready to guide athlete training or prevention; leaves open needs for standardized, diverse prospective validation.
, influencing energy metabolism, angiogenesis, and cardiovascular function. This review underscores the benefits of a multi-omics approach to better understand the complex interactions between genetic polymorphisms and physiological traits. It also addresses long-standing issues such as small sample sizes in studies and the heterogeneity in heritability estimates influenced by factors like sex. Understanding the mechanistic relationship between genetics and endurance performance can lead to personalized training strategies, injury prevention, and improved health outcomes. Future studies should focus on standardized classification of sports, replication studies involving diverse populations, and establishing solid physiological associations between polymorphisms and endurance traits to advance the field of sports genetics.
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Bıçakçı et al. (2024) conducted a review in Endurance performance and elite athlete status. Genetic determinants of endurance performance, evaluated through a multi-omics approach, can elucidate complex physiological interactions to guide personalized training and injury prevention.
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