What question did this study set out to answer?

This study aims to evaluate how well established cancer cell lines represent clinical cancer samples in terms of drug resistance mechanisms.

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

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Investigating drug resistance in cancers reveals that existing cell lines poorly model clinical samples, suggesting new approaches.

This study aims to evaluate how well established cancer cell lines represent clinical cancer samples in terms of drug resistance mechanisms.
Investigated multidrug resistance transcriptome in six cancer types using Taqman-based quantitative RT-PCR.
Analyzed established cancer cell lines grown in different conditions (monolayer, 3D scaffold, xenograft) and clinical samples.
Curated an MDR transcriptome consisting of 380 genes based on literature from the past 30 years.
No correlation was found between clinical cancer samples and established cancer cell lines.
Cell lines showed up-regulation of genes related to survival across all evaluated types.
Cell lines were more similar to each other than to the clinical samples, regardless of tissue origin.

Gillet et al. (2011) studied this question.

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