Self-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus: The SWEDEHEART Registry

Figure 1. Patient selection process. ∗Only Evolut valves, Portico/Navitor valves, and Acurate vaves were included. Abbreviations: CT, computed tomography; SWENTRY registry, SWEdish traNscatheter cardiac intervention regisTRY; TAVR, transcatheter aortic valve replacement; THVs, transcatheter heart valves; VARC, Valve Academic Research Consortium.

Figure 2. Standardized mean differences across covariates before and after inverse probability of treatment weighting. The dotted lines represent standardized mean differences of ±0.10. Abbreviations: BMI, body mass index; CKD, chronic kidney disease; EF, ejection fraction; HFrEF, heart failure with reduced ejection fraction; HFmrEF, heat failure with mildly reduced ejection fraction; LVEF, left ventricular ejection fraction; NTproBNP, N-terminal prohorme of brain natriuretic peptide; NYHA, New York Heart Association; PCI,percutaneous coronary intervention; sPAP, systolic pulmonary artery pressure; TAVI, transcathter aortic valve implantation; TAVR, transcatheter aortic valve replacement.

Figure 3. Nonadjusted (Panel a and b) and IPTW-adjusted Kaplan-Meier curves (Panel c and d) of all-cause mortality in patients with small aortic annulus. At a median follow-up of 969 days (IQR: 478-1452 days), Abbott/Portico valves were associated with higher unadjusted mortality compared to Evolut valves (Panel a); however, this difference was not statistically significant after IPTW adjustment (Panel c). No significant differences in mortality were observed between Acurate and Evolut valves in either the unadjusted or IPTW-adjusted analyses. SAVs demonstrated lower unadjusted mortality compared to IAVs (Panel b), but this difference was not significant after IPTW adjustment (Panel d). Note: Number at risk is not applicable for IPTW-adjusted analyses. Abbreviations: HR, hazard ratio; IAV, intra-annular valve; IPTW, inverse probability of treatment weighting; IQR, interquartile range; SAV, supra-annular valve.

Figure 4. Mean post-TAVR aortic valve gradients across different manufacturers (a) and according to THV valve position (b). Abbreviations: TAVR, transcatheter aortic valve replacement; THV, transcatheter heart valve.