What question did this study set out to answer?

The aim is to assess the impact of pre-hospital thrombolysis on treatment delays and mortality in STEMI patients.

April 19, 2006European Heart JournalOpen Access

Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction

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Why the study?

Does pre-hospital thrombolysis delivered by paramedics reduce 1-year mortality and treatment delays in ambulance-transported STEMI patients compared to in-hospital thrombolysis?

Population

5,375 ambulance-transported thrombolytic-treated patients younger than age 80 with a diagnosis of acute…

Comparison

Pre-hospital thrombolysis delivered by trained… vs Regular in-hospital thrombolysis.

Design

Cohort

Follow-up

1 year

Authors

EBErik BjörklundUppsala University Hospital USUlf StenestrandInterventional Cardiology JLJohan LindbäckGeneral Cardiology

Discussion

Member takes

Implication

May support pre-hospital thrombolysis in STEMI; leaves open need for randomized confirmation.

Key Points

The aim is to assess the impact of pre-hospital thrombolysis on treatment delays and mortality in STEMI patients.
Prospective cohort study based on data from the Swedish Register of Cardiac Intensive Care.
Included patients under 80 years with ST-elevation myocardial infarction transported by ambulance.
Compared outcomes between pre-hospital thrombolysis and in-hospital thrombolysis.
Median time from symptom onset to treatment was 113 min for PHT vs. 165 min for in-hospital treatment.
One-year mortality was 7.2% for PHT compared to 11.8% for in-hospital thrombolysis.
PHT associated with lower adjusted one-year mortality (odds ratio 0.71, 95% CI 0.55-0.92, p=0.008).

Structured PICO

Does pre-hospital thrombolysis delivered by paramedics reduce 1-year mortality and treatment delays in ambulance-transported STEMI patients compared to in-hospital thrombolysis?

Population

5,375 ambulance-transported thrombolytic-treated patients younger than age 80 with a diagnosis of acute ST-elevation myocardial infarction (STEMI) admitted to 75 Swedish hospitals between 2001-2004.

Intervention

Pre-hospital thrombolysis (PHT) delivered by trained paramedics in ambulances.

Comparator

Regular in-hospital thrombolysis.

Outcome

1-year mortality.hard clinical

Pre-hospital thrombolysis delivered by paramedics significantly reduces time to treatment and 1-year mortality in real-world STEMI patients compared to in-hospital thrombolysis.

Cite This Study

Björklund et al. (2006) studied this question.

synapsesocial.com/papers/6a07f77e686e45fdbcfe0d5b https://doi.org/10.1093/eurheartj/ehi886

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Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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