Key result
Post-PCI troponin elevation >3 times the diagnostic level was associated with 1-year mortality (adjusted HR 1.7; 95% CI 1.1-2.5), but a >20-fold increase was needed to match the risk of >3-fold CKMB.
Why the study?
Does the threshold of troponin elevation after percutaneous coronary intervention correlate with 1-year mortality similarly to CKMB elevation?
Population
4,930 patients with elective coronary stent placement between July 1, 2004, and September 30, 2007, from the…
Comparison
Postprocedure elevation of troponin vs Postprocedure elevation of CKMB
Design
Cohort
Follow-up
1 year
Authors
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Current troponin thresholds may overestimate post-PCI MI risk; leaves open validation of higher cutoffs in prospective studies.
Cohort (n=4,930)
Yes
Does the threshold of troponin elevation after percutaneous coronary intervention correlate with 1-year mortality similarly to CKMB elevation?
Effect estimate: adjusted HR 1.7 (95% CI 1.1-2.5)
A troponin elevation >20 times the diagnostic limit after elective PCI provides a similar frequency and 1-year mortality risk as a >3-fold increase in CKMB, suggesting current universal definition thresholds for troponin may be too low.
Victor Novack (2012) conducted a cohort in elective coronary stent placement (n=4,930). Troponin elevation >3 times diagnostic level vs. CKMB elevation >3 times diagnostic level was evaluated on 1-year mortality (adjusted HR 1.7, 95% CI 1.1-2.5). Post-PCI troponin elevation >3 times the diagnostic level was associated with 1-year mortality (adjusted HR 1.7; 95% CI 1.1-2.5), but a >20-fold increase was needed to match the risk of >3-fold CKMB.
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