Health Status Predicts Long-Term Outcome in Outpatients With Coronary Disease
Key result
Lower Seattle Angina Questionnaire physical limitation scores independently predicted 1-year mortality, with severe limitation having an odds ratio of 4.0 compared to minimal limitation (P<0.001).
Why the study?
Do patient-reported health status measures using the Seattle Angina Questionnaire (SAQ) predict 1-year mortality and ACS hospitalization in outpatients with coronary disease?
Population
5,558 outpatients with coronary artery disease from 6 Veterans Affairs General Internal Medicine Clinics
Comparison
Seattle Angina Questionnaire assessment vs Comparison across different SAQ score severity…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May aid mortality risk stratification in stable CAD outpatients; leaves open whether SAQ-guided interventions improve outcomes.
Key Points
- This study aims to determine if patient-reported health status measures can independently predict mortality and hospitalizations in outpatients with coronary disease.
- Prospective cohort study at 6 Veterans Affairs clinics
- Included 5558 patients with coronary artery disease who completed a Seattle Angina Questionnaire (SAQ) with 1 year follow-up
- Analyzed associations between SAQ scores and outcomes of mortality and acute coronary syndrome hospitalizations.
- Lower SAQ scores significantly correlated with increased risks of mortality and ACS admissions, P<0.001
- Odds ratios for mortality were 1.5, 2.0, and 4.0 for physical limitations compared to minimal limitation, respectively
- ACS admission odds ratios were 1.4, 2.0, and 2.2 for increasing angina frequency, P=0.016
Study Design
Type
Cohort (n=5,558)
Multicenter
Yes
Structured PICO
Do patient-reported health status measures using the Seattle Angina Questionnaire (SAQ) predict 1-year mortality and ACS hospitalization in outpatients with coronary disease?
P
Population
5,558 outpatients with coronary artery disease from 6 Veterans Affairs General Internal Medicine Clinics
I
Intervention
Seattle Angina Questionnaire (SAQ) assessment (evaluating physical limitation, angina stability, angina frequency, and quality-of-life scores)
C
Comparator
Comparison across different SAQ score severity levels (minimal, mild, moderate, severe)
O
Outcome
1-year all-cause mortalityhard clinical
Main Result
Effect estimate: OR 4.0
p-value: p=<0.001
Patient-reported health status using the SAQ independently predicts 1-year mortality and ACS hospitalization in outpatients with coronary disease, highlighting its value for clinical risk stratification.
Cite This Study
Spertus et al. (2002) conducted a cohort in coronary artery disease (n=5,558). Seattle Angina Questionnaire (SAQ) scores vs. Minimal limitation was evaluated on 1-year all-cause mortality (OR 4.0, p=<0.001). Lower Seattle Angina Questionnaire physical limitation scores independently predicted 1-year mortality, with severe limitation having an odds ratio of 4.0 compared to minimal limitation (P<0.001).