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February 1, 2020Panminerva Medica

Gender differences in clinical characteristics, medical management, risk factor control, and long-term outcome of patients with stable coronary artery disease: from the CORONOR registry

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Key result

Women with stable CAD face similar 5-year risk of major cardiovascular events compared to men.

  • HR 1.03
  • 95% CI 0.81-1.31
  • P=0.817
  • n=4,184

Why the study?

Conflicting information exists regarding whether sex differences modulate outcomes in patients with coronary artery disease.

Does female sex modulate long-term cardiovascular outcomes in patients with stable CAD compared to male sex?

Population

4184 consecutive outpatients with stable CAD

Comparison

Women vs men

Design

Multicenter registry

Follow-up

5 years

Authors

AMAnne‐Laure MadikaUniversité Paris-SudGLGilles LemesleInterventional CardiologyNLNicolas LamblinHeart Failure & Transplant

Discussion

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Implication

Similar adjusted outcomes despite poorer risk factor control in women; leaves open whether targeted interventions improve prognosis in stable CAD.

Study Design

Type

Cohort (n=4,184)

Multicenter

Yes

Structured PICO

Does female sex modulate long-term cardiovascular outcomes in patients with stable CAD compared to male sex?

P
Population
4,184 consecutive outpatients with stable coronary artery disease (CAD) from the multicenter CORONOR registry (77.7% men, 22.3% women)
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Composite of cardiovascular death, myocardial infarction, or ischemic stroke at 5 yearscomposite

Main Result

Effect estimate: HR 1.03 (95% CI 0.81-1.31)

p-value: p=0.817

Despite poorer control of cardiovascular risk factors, women with stable CAD have similar 5-year cardiovascular outcomes compared to men.

Cite This Study

Madika et al. (2020) conducted a cohort in stable coronary artery disease (n=4,184). Female gender vs. Male gender was evaluated on cardiovascular death, myocardial infarction, or ischemic stroke (HR 1.03, 95% CI 0.81-1.31, p=0.817). Women with stable coronary artery disease had similar 5-year rates of cardiovascular death, myocardial infarction, or ischemic stroke compared to men (HR 1.03; 95% CI 0.81-1.31; P=0.817).

synapsesocial.com/papers/6a07f7c8eda89529367358b5https://doi.org/10.23736/s0031-0808.18.03525-5

Topics

Coronary artery diseaseHypertension managementWomen and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gender differences in management and outcome in non-ST-elevation acute coronary syndrome2006 · 155 citations
  2. 2Sex and Ethnic Differences in Outcomes of Acute Coronary Syndrome and Stable Angina Patients With Obstructive Coronary Artery Disease2016 · 32 citations
  3. 3Persisting gender differences and attenuating age differences in cardiovascular drug use for prevention and treatment of coronary heart disease, 1998–20102013 · 132 citations
  4. 4Incidence, Source, Determinants, and Prognostic Impact of Major Bleeding in Outpatients With Stable Coronary Artery Disease2014 · 102 citations
  5. 5Long-term prognostic impact of left ventricular remodeling after a first myocardial infarction in modern clinical practice2017 · 39 citations