Key result
Triple antithrombotic therapy was well tolerated and did not lead to progression of the intimal flap after 6 months in a 51-year-old man with acute type B aortic dissection.
Why the study?
The study was conducted to evaluate sex differences in culprit plaque features assessed by optical coherence tomography and major adverse cardiovascular events at follow-up in patients with acute coronary syndrome.
Does female sex impact culprit plaque features at OCT and MACE at follow-up in patients with acute coronary syndrome?
Case Report (n=1)
No
Does female sex impact culprit plaque features at OCT and MACE at follow-up in patients with acute coronary syndrome?
Female sex does not significantly impact culprit plaque rupture risk or major adverse cardiovascular events in patients with acute coronary syndrome evaluated by OCT.
Aim: To evaluate sex difference in culprit plaque features at optical coherence tomography (OCT) and major adverse cardiovascular events at follow-up. Patients and methods: We analyse data from the OCT-FORMIDABLE (OCT-Features Of moRphology, coMposItion anD instABility of culprit and pLaquE in acute coronary syndrome [ACS] patients) registry. A total of 285 patients (20%, 58 females) were included. Results: Females with ST segment elevation myocardial infarction showed a longer ruptured area of the plaque (8.6 ± 7.6 vs 4.6 ± 5.4; p = 0.003) and a major necrotic core macrophage infiltration (43 vs 17%; p = 0.017). Females with non-ST segment elevation-ACS had less lipidic plaques (62 vs 80%; p = 0.04). No between-group sex differences in major adverse cardiovascular events emerged at follow-up (5 vs 9%; p = 0.88 in ST segment elevation myocardial infarction group and 19 vs 15%; p = 0.6 in non-ST segment elevation-ACS group). At multivariate analysis, female sex was not a major risk of plaque rupture (hazard ratio [HR]: 1.59, CI: 0.44-5.67; p = 0.48). Conclusion: Female sex seems to have no significant impact. ClincalTrial. gov registration number: NCT02486861.
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Giordana et al. (2020) conducted a case report in Acute type B aortic dissection (n=1). Triple antithrombotic therapy (warfarin, acetylsalicylic acid, clopidogrel) was evaluated on Progression of aortic dissection. Triple antithrombotic therapy was well tolerated and did not lead to progression of the intimal flap after 6 months in a 51-year-old man with acute type B aortic dissection.
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