Key result
Female gender is linked to a ~6% lower 12-month mortality risk in NSTEMI patients.
Why the study?
Gender-related differences in the treatment of NSTEMI have been previously reported despite guidelines recommending an equal approach, prompting investigation into whether these discrepancies have changed.
Are there gender-related disparities in the treatment and outcomes of patients with NSTEMI?
Cohort (n=66,667)
Yes
Are there gender-related disparities in the treatment and outcomes of patients with NSTEMI?
Effect estimate: RR 0.94 (95% CI 0.92-0.97)
Absolute Event Rate: 15.1% vs 12.8%
p-value: p=<0.0001
Gender-related disparities in NSTEMI treatment and outcomes have been radically reduced, with age-adjusted mortality now similar between men and women.
Lower adjusted mortality in women with NSTEMI; leaves open whether this reflects biology or residual confounding in observational data.
INTRODUCTION: Gender-related differences in the treatment of patients with non-ST elevation myocardial infarction (NSTEMI) have been reported in many previous studies despite the fact that an equal approach is recommended in all current guidelines. The aim of the study was to investigate whether gender-related discrepancies in the management of NSTEMI patients have changed. MATERIAL AND METHODS: Between 2012 and 2014 a total of 66,667 patients (38.3% of whom were women) with the final diagnosis of NSTEMI were included into the retrospective analysis of the Polish Registry of Acute Coronary Syndromes (PL-ACS). Differences in clinical profile, treatment, and outcomes were analysed. RESULTS: < 0.0001). CONCLUSIONS: In comparison with previous reports on NSTEMI patients, gender-related disparities in the treatment and outcomes were radically reduced. Unadjusted mortality rates were still higher in women as a consequence of their older age. After the age adjustment, mortality ratios were similar in both genders. The long-term prognosis seems to be even better in women.
No takes yet. Share an insight, caveat, or question.
Piątek et al. (2020) conducted a cohort in Non-ST elevation myocardial infarction (NSTEMI) (n=66,667). Female gender vs. Male gender was evaluated on 12-month mortality (RR 0.94, 95% CI 0.92-0.97, p=<0.0001). In patients with NSTEMI, female gender was associated with a lower risk of 12-month mortality compared to men (RR 0.94) after adjusting for age and other covariates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: