Sex Differences in Evaluation and Outcome of Unstable Angina
Key result
Male sex was associated with higher use of invasive cardiac procedures (RR 1.72; 95% CI 1.51-1.97) and an increased risk of cardiac events (RR 1.21; 95% CI 1.03-1.42) compared to female sex.
Why the study?
Does female sex reduce the use of cardiac procedures and worsen outcomes in patients presenting with unstable angina?
Population
2,271 residents presenting to the emergency department for the first time with symptoms meeting criteria for…
Comparison
Female sex vs Male sex
Design
Cohort
Follow-up
average of 6 years
Authors
Discussion
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Member takes
Implication
Should not yet change practice; extends observational data on sex differences in unstable angina care and outcomes.
Study Design
Type
Cohort (n=2,271)
Multicenter
Yes
Structured PICO
Does female sex reduce the use of cardiac procedures and worsen outcomes in patients presenting with unstable angina?
P
Population
2,271 residents (1,306 men and 965 women) presenting to the emergency department for the first time with symptoms meeting criteria for unstable angina
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Use of cardiac procedures within 90 days of ED visit, overall mortality, and cardiac events (cardiac death, nonfatal myocardial infarction, nonfatal cardiac arrest, and congestive heart failure)composite
Main Result
Effect estimate: RR 1.21 (95% CI 1.03-1.42)
Despite women receiving fewer cardiac procedures after presenting with unstable angina, men experienced worse long-term cardiovascular outcomes after adjusting for baseline characteristics.
Cite This Study
Véronique L. Roger (2000) conducted a cohort in Unstable angina (n=2,271). Male sex vs. Female sex was evaluated on Cardiac events (cardiac death, nonfatal myocardial infarction, nonfatal cardiac arrest, and congestive heart failure) (RR 1.21, 95% CI 1.03-1.42). Male sex was associated with higher use of invasive cardiac procedures (RR 1.72; 95% CI 1.51-1.97) and an increased risk of cardiac events (RR 1.21; 95% CI 1.03-1.42) compared to female sex.