Key result
Global ischemic heart disease mortality fell ~32% from 1990 to 2021.
Why the study?
With a rapidly growing and aging population, ischemic heart disease remains a major burden, requiring a reassessment of prevalence trends from 1990 to 2021 to improve on previous studies and inform policy.
Population
Global population across 204 countries, 21 GBD geographic regions, and five SDI regions
Comparison
Differences based on age, sex, SDI regions, geographic regions, and countries from 1990 to 2021
Design
Epidemiologic modeling study using Global Burden of Disease 2021 data
Authors
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Declining IHD mortality rates are offset by rising absolute burden from aging; leaves open optimal prevention strategies amid demographic shifts.
Observational
Effect estimate: EAPC -1.3 (95% CI -1.33 to -1.27)
Absolute Event Rate: 108.73% vs 158.9%
Despite declining age-standardized rates of IHD mortality and incidence, the absolute global burden of IHD is increasing significantly due to population growth and aging.
Cheng et al. (2025) conducted an observational in Ischemic heart disease. Time period (2021) vs. Time period (1990) was evaluated on Age-standardized mortality rate (ASMR) per 100,000 people (EAPC -1.3, 95% CI -1.33 to -1.27). From 1990 to 2021, the global age-standardized mortality rate of ischemic heart disease decreased from 158.9 to 108.73 per 100,000 people, with an estimated annual percentage change of -1.3.
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