What is the clinical evidence from this study?

Study design: Observational. Population: Acute coronary syndrome (n=60). Intervention: Hyperglycemia (glucose >7.0 mmol/l) vs. Normoglycemia (glucose <7.0 mmol/l). Primary outcome: Generation of thrombin-antithrombin complexes (TATs) and soluble CD40 ligand (sCD40L), ex vivo plasma fibrin clot permeability and lysis time (p=< 0.0001).

What question did this study set out to answer?

The study aims to evaluate how elevated glucose levels affect blood clotting in acute coronary syndrome patients, with and without diabetes.

June 7, 2008Diabetes CareOpen Access

Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome

Q: What are the key findings of this study?

Hyperglycemia in acute coronary syndrome patients without prior diabetes increased maximum TAT formation by 42.9% (P<0.0001) and prolonged clot lysis time by ~18% (P<0.0001) versus normoglycemia.

Q: What question did this study set out to answer?

The study aims to evaluate how elevated glucose levels affect blood clotting in acute coronary syndrome patients, with and without diabetes.

View Full Paper

Ask AI

Bookmark

Key result

Hyperglycemia in acute coronary syndrome patients without prior diabetes increased maximum TAT formation by 42.9% (P<0.0001) and prolonged clot lysis time by ~18% (P<0.0001) versus normoglycemia.

Why the study?

Does hyperglycemia or type 2 diabetes increase thrombin formation, platelet activation, and clot resistance in patients with acute coronary syndrome?

Population

60 acute coronary syndrome patients within the first 12 h after pain onset, including 20 subjects with type…

Comparison

Hyperglycemia or known type 2 diabetes vs Normoglycemia (glucose <7.0 mmol/l)

Design

Cross-sectional

Authors

AUAnetta UndasVascular Medicine IWIlona WiekJohn Paul II Hospital ESEwa StępieńJagiellonian University

Discussion

Member takes

Implication

Hyperglycemia may exacerbate thrombotic risk in nondiabetic ACS; hypothesis-generating and requires confirmation in interventional studies.

Key Points

The study aims to evaluate how elevated glucose levels affect blood clotting in acute coronary syndrome patients, with and without diabetes.
Analyzed 60 acute coronary syndrome patients within 12 hours after pain onset, categorized by glucose levels.
Measured thrombin-antithrombin complexes and soluble CD40 ligand at microvascular injury sites.
Assessed plasma fibrin clot permeability and lysis time in different glucose level groups.
Non-diabetic patients with hyperglycemia had 42.9% increased thrombin formation (P < 0.0001).
Patients with elevated glucose levels showed an 18% increase in clot lysis time (P < 0.0001).
Diabetic patients had the highest values for thrombin and sCD40L compared to normoglycemic individuals (P < 0.0001).

Study Design

Type

Observational (n=60)

Structured PICO

Does hyperglycemia or type 2 diabetes increase thrombin formation, platelet activation, and clot resistance in patients with acute coronary syndrome?

Population

60 acute coronary syndrome patients within the first 12 h after pain onset, including 20 subjects with type 2 diabetes, 20 subjects with no diagnosed diabetes but with glucose levels >7.0 mmol/l, and 20 subjects with glucose levels <7.0 mmol/l.

Intervention

Hyperglycemia (glucose >7.0 mmol/l) or known type 2 diabetes

Comparator

Normoglycemia (glucose <7.0 mmol/l)

Outcome

Generation of thrombin-antithrombin complexes (TATs) and soluble CD40 ligand (sCD40L) at the site of microvascular injury, together with ex vivo plasma fibrin clot permeability and lysis timesurrogate

Main Result

p-value: p=< 0.0001

Hyperglycemia in acute coronary syndrome is associated with enhanced local thrombin generation, platelet activation, and unfavorably altered clot features, providing a potential mechanism for worse prognosis.

Cite This Study

Undas et al. (2008) conducted an observational in Acute coronary syndrome (n=60). Hyperglycemia (glucose >7.0 mmol/l) vs. Normoglycemia (glucose <7.0 mmol/l) was evaluated on Generation of thrombin-antithrombin complexes (TATs) and soluble CD40 ligand (sCD40L), ex vivo plasma fibrin clot permeability and lysis time (p=< 0.0001). Hyperglycemia in acute coronary syndrome patients without prior diabetes increased maximum TAT formation by 42.9% (P<0.0001) and prolonged clot lysis time by ~18% (P<0.0001) versus normoglycemia.

synapsesocial.com/papers/6a07f88509b3c82015378df3 https://doi.org/10.2337/dc08-0282

View Full Paper

Ask AI

Bookmark

Implication

Hyperglycemia may exacerbate thrombotic risk in nondiabetic ACS; hypothesis-generating and requires confirmation in interventional studies.

Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider