July 23, 2007Archives of Internal Medicine
Short-term Variability in Measures of Glycemia and Implications for the Classification of Diabetes
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Discussion
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Implication
Randomized trial examines glycemic variability and its impact on diabetes classification, suggesting implications for diagnosis accuracy.
Key Points
- The aim was to explore short-term variability in glycemic measures and its impact on diabetes classification.
- Analyzed repeated measurements from 685 fasting participants without diagnosed diabetes
- Participants were from the National Health and Nutrition Examination Survey III
- Repeated examinations conducted approximately 2 weeks after the original examination.
- Two-hour glucose variability (CV(w), 16.7%) was significantly greater than fasting glucose (CV(w), 5.7%) and HbA1c (CV(w), 3.6%)
- 70.4% of individuals with a fasting glucose of 126 mg/dL or higher had a second measurement at or above that threshold
- Prevalence of undiagnosed diabetes decreased from 3.7% to 2.8% when using a second fasting glucose measurement.
Cite This Study
Elizabeth Selvin (2007) studied this question.