Key result
Better global self-care is linked to lower GFR, suggesting it reflects worsening renal function.
Why the study?
Self-care is assumed to benefit physiological function linked to prognosis in chronic HF, but studies evaluating these relationships are lacking.
Does self-reported HF self-care improve HF-associated pathophysiological markers in patients with chronic heart failure?
Observational (n=460)
Yes
Does self-reported HF self-care improve HF-associated pathophysiological markers in patients with chronic heart failure?
While exercise and medication adherence are associated with improved physiological functioning, fluid and sodium restriction may be associated with adverse pathophysiological biomarker levels in chronic heart failure.
Answers are grounded in this paper and cite their sources.
Self-care reports may signal worsening renal function in HF; leaves open whether interventions modify biomarkers.
BACKGROUND: Self-care is assumed to benefit physiological function associated with prognosis in patients with chronic HF, but studies examining these relations are lacking. This study aims to prospectively examine the association of self-reported HF self-care with HF-associated pathophysiological markers, including renal, hematological, and immune function. METHOD: ), and hemoglobin (Hb), controlling for sociodemographic and clinical covariates. RESULTS: (P = .014). Low-sodium intake was associated with lower levels of Hb (P = .027), lower TNF-alpha (P = .011), and lower IL-10 (P = .029). Higher levels of medication adherence were associated with reduced pro-inflammatory activation (P < .007). CONCLUSION: Our findings suggest that better global self-care was associated with poorer renal function. Performing self-care behaviors such as regular exercise and medication adherence was associated with improved physiological functioning, while restriction of fluid and sodium, and the associated daily weight monitoring were associated with adverse levels of pathophysiological biomarkers.
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Kessing et al. (2019) conducted an observational in Chronic Heart Failure (n=460). Self-care behaviors was evaluated on Glomerular filtration rate of creatinine (GFRcreat) (β = -0.14, p=0.023). Better global self-care was independently associated with lower glomerular filtration rate of creatinine (β = -0.14, P = 0.023), suggesting that increased self-care may reflect worsening renal function.
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