What question did this study set out to answer?

This study investigates the relationship between specific hepatic sphingolipids and metabolic dysfunctions in obese individuals with and without nonalcoholic fatty liver disease.

March 30, 2018Diabetes Care

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

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Authors

MAMaria ApostolopoulouUniversity of Thessaly RGRuth GordilloSouthwestern Medical Center CKChrysi KoliakiLaiko General Hospital of Athens

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Implication

Randomized trial examines sphingolipids' role in insulin resistance and inflammation in obese individuals with liver disease, suggesting a crucial relationship.

Key Points

This study investigates the relationship between specific hepatic sphingolipids and metabolic dysfunctions in obese individuals with and without nonalcoholic fatty liver disease.
Examined 21 insulin-resistant obese patients with (NAFL+) and without (NAFL-) NASH, and 7 healthy controls before bariatric surgery.
Measured hepatic oxidative capacity, lipid peroxidation, and pJNK-to-tJNK ratio to assess metabolism and inflammation.
Evaluated correlations between sphingolipids and insulin sensitivity using tissue biopsies. Support for correlations was drawn from serum and hepatic lipid analyses.
Hepatic total ceramides were 50% higher in NASH compared to NAFL+ and 33% higher than NAFL-.
Negative correlation between serum total ceramides and whole-body insulin sensitivity was observed in NASH individuals.
Positive relationships found between hepatic maximal respiration and specific serum lactosylceramide and sphinganine subspecies.

Cite This Study

Apostolopoulou et al. (2018) studied this question.

synapsesocial.com/papers/6a08065dad370a6b44ddeaac https://doi.org/10.2337/dc17-1318

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Implication

Randomized trial examines sphingolipids' role in insulin resistance and inflammation in obese individuals with liver disease, suggesting a crucial relationship.

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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