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The aim is to develop rapid diagnostic tools and preventive strategies for oral diseases, focusing on proteases in tissues and saliva.

May 16, 2026Open Access

Development of Diagnostic and Preventive Systems for the Oral Cavity

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The aim is to develop rapid diagnostic tools and preventive strategies for oral diseases, focusing on proteases in tissues and saliva.
Developed point-of-care probes for detecting proteases in head and neck squamous cell carcinoma during surgery.
Created saliva-based tests for COVID-19 proteases using multiplexable probes for quick detection.
Implemented Direct Pan-Protease Profiling to analyze active proteases in saliva samples without prior identification.
The probes provided rapid differentiation of tumor margins from healthy tissue within minutes.
Saliva-based tests showed potential for easier COVID-19 diagnosis compared to conventional methods.
DiPPP enabled the profiling of all active proteases in saliva, highlighting disease-specific patterns.

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Randomized trial develops simple diagnostic tools for oral diseases, suggesting improved outcomes for prevention.

Debora Reinhardt (2026) studied this question.

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