Editorial: The regeneration and intervention of neurological tissue after acute and chronic injuries: from benchside to bedside

standard of care has remained largely unchanged. Autologous nerve transplantationthe gold standard for direct repair-is constrained by limited tissue availability and suboptimal outcomes [5]. Alternative approaches often compensate for lost function rather than restoring it, highlighting a pressing unmet clinical need.Recently, however, the landscape has shifted. Advances in materials science, stem cell biology, drug delivery, and physical therapeutics have sparked a wave of innovation. Biomaterials engineered to mimic the extracellular matrix support axonal regrowth [6]. Cell-based therapies offer the potential to replace lost neurons and modulate the injury environment [7]. Novel pharmaceuticals target regenerationinhibiting pathways, while neuromodulation and brain-machine interfaces aim to restore function at the systems level [8]. This special issue captures the breadth of this evolving field, encompassing acute and chronic injuries to peripheral nerves, the spinal cord, and the brain. We invited leading researchers to share their findings in this forum with two primary goals: to provide a comprehensive overview of the current state of neural repair research, and to foster the cross-disciplinary dialogue necessary to propel the field forward. By bringing together diverse perspectives and approaches, we hope to lay a more robust foundation for future translational efforts-and ultimately, to accelerate the development of therapies that restore not just function, but quality of life, to patients suffering from neurological injury. On behalf of the guest editors, I extend our sincere gratitude to the editorial team and all publishing staff for their diligent behind-the-scenes work. We thank all the scientists who submitted their work to this special issue-whether their manuscripts were accepted or not-for their years of dedication and deep commitment to advancing the field of neural repair. We are also deeply grateful to the reviewers for their selfless, rigorous, and impartial contributions. We believe that the findings and perspectives presented here will, much like action potentials, travel onward-guiding the field toward broader horizons, deeper insights, and more forward-looking directions.Thank you all.