Key result
Prehypertension increased all-cause mortality (HR 1.49; 95% CI 1.12-1.99), but this risk was only significant when combined with upper tertile pulse pressure (HR 2.14; 95% CI 1.38-3.32).
Why the study?
Does pulse pressure impact the relationship between prehypertension and mortality in individuals free of diabetes and cardiovascular disease?
Cohort (n=3,632)
Does pulse pressure impact the relationship between prehypertension and mortality in individuals free of diabetes and cardiovascular disease?
Effect estimate: HR 1.49 (95% CI 1.12-1.99)
Prehypertension increases mortality risk in individuals free of diabetes and cardiovascular disease, but this risk is primarily driven by those with a wider pulse pressure.
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Pulse pressure may refine prehypertension mortality risk stratification; leaves open whether targeting it improves outcomes.
Lorenzo‐Bosquet et al. (2009) conducted a cohort in Prehypertension (n=3,632). Prehypertension vs. Normal blood pressure was evaluated on All-cause mortality (HR 1.49, 95% CI 1.12-1.99). Prehypertension increased all-cause mortality (HR 1.49; 95% CI 1.12-1.99), but this risk was only significant when combined with upper tertile pulse pressure (HR 2.14; 95% CI 1.38-3.32).
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