Key result
Insulin induces direct vasodilation in skeletal muscle and stimulates the sympathetic nervous system, though direct evidence supporting a causative role in cardiovascular disease is not yet available.
This review highlights the dual hemodynamic actions of insulin—vasodilation and sympathetic stimulation—and notes the lack of direct evidence for its causative role in cardiovascular disease.
Insulin's hemodynamic effects should not yet alter clinical practice; leaves open any causative cardiovascular disease role.
Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation of the sympathetic nervous system. These closely linked effects normally offset each other. Although more insight has been obtained into responses in insulin-resistant individuals and possible mechanisms, direct evidence to support a causative role for insulin is not yet available.
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Tack et al. (1998) conducted a review in cardiovascular disease. insulin was evaluated. Insulin induces direct vasodilation in skeletal muscle and stimulates the sympathetic nervous system, though direct evidence supporting a causative role in cardiovascular disease is not yet available.
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