Why the study?
Are pulmonary function, heart rate, uric acid, and serum cholesterol predictive of developing incident essential hypertension?
Population
2,062 individuals from the Kaiser Permanente Multiphasic Health Checkup cohort in Northern California
Comparison
Higher levels of forced vital capacity, serum… vs Lower levels of the respective measurements
Design
Case-control
Key result
Higher forced vital capacity was inversely associated with incident hypertension (OR 0.22; 95% CI 0.11-0.46), while higher serum uric acid increased risk (OR 2.19; 95% CI 1.20-3.98).
Authors
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Lower forced vital capacity and higher uric acid were associated with incident hypertension; leaves open their causal role and utility as preventive markers.
Case-Control (n=2,062)
Are pulmonary function, heart rate, uric acid, and serum cholesterol predictive of developing incident essential hypertension?
Effect estimate: OR 0.22 (95% CI 0.11-0.46)
p-value: p=<0.001
Lower forced vital capacity and higher serum uric acid are independent predictors of incident essential hypertension, suggesting they may serve as markers of susceptibility.
Selby et al. (1990) conducted a case-control in Essential hypertension (n=2,062). Forced vital capacity and serum uric acid vs. Lower quintiles was evaluated on Incident essential hypertension (OR 0.22, 95% CI 0.11-0.46, p=<0.001). Higher forced vital capacity was inversely associated with incident hypertension (OR 0.22; 95% CI 0.11-0.46), while higher serum uric acid increased risk (OR 2.19; 95% CI 1.20-3.98).