Dynamics and static pupillometry in congenital Brown syndrome

PURPOSE: Brown syndrome is conventionally regarded as a mechanical restriction of elevation in adduction, yet congenital cases have been presented that overlap with congenital cranial dysinnervation disorders (CCDDs), raising the possibility of subtle autonomic or neurogenic involvement. METHODS: ) conditions. Dynamic recordings included initial diameter; contraction amplitude, latency, duration, and velocity; and dilation latency, duration, and velocity. CONCLUSIONS: Static and dynamic pupillary functions appear preserved in unilateral congenital Brown syndrome, with no measurable involvement of pupillary autonomic pathways in the studied sample. Larger, multicenter studies are warranted to detect any subtle effects and to further clarify Brown syndrome pathophysiology within the proposed CCDD spectrum.