Conjugation of Dietary Carnosine to Phe-Leu Dipeptide Affords a Potent Inhibitor of Multifaceted Aβ-Induced Neurotoxicity | Synapse
May 16, 2026
Conjugation of Dietary Carnosine to Phe-Leu Dipeptide Affords a Potent Inhibitor of Multifaceted Aβ-Induced Neurotoxicity
Key Points
The study aims to evaluate the role of carnosine conjugated to the dipeptide FL as an inhibitor of Aβ-induced neurotoxicity in Alzheimer's disease.
Utilized a conjugation approach to combine carnosine with the dipeptide Phe-Leu.
Assessed the neurotoxic effects induced by Aβ in cellular models.
Carnosine-FL conjugate significantly reduced Aβ-induced cytotoxicity in experimental models.
Showed a robust potential as a neuroprotective agent against misfolded protein-induced damage.
Abstract
misfolding. To our knowledge, the present study for the first time depicts the synergistic potential of carnosine conjugated to FL as an inhibitor of multifaceted Aβ-induced cytotoxicity in AD.