Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies

May 13, 2026BMC CancerOpen Access

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Key Points

This study evaluates the relationship between oral health conditions and colorectal cancer risk, focusing on periodontitis, tooth loss, and dental caries.
Systematic evaluation of observational studies from multiple databases for association with CRC risk.
Meta-analysis utilizing adjusted hazard ratios with 95% confidence intervals.
Subgroup and sensitivity analyses to explore heterogeneity and robustness of findings.
Periodontitis shows a significant association with increased CRC risk.
No significant association for tooth loss (HR = 1.08, 95% CI: 0.98-1.19) or dental caries (HR = 1.10, 95% CI: 0.91-1.32).
Dose-response analysis indicates no significant relationship between the number of missing teeth and CRC risk (HR = 1.03, 95% CI: 0.96-1.10).

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Observational analyses assess oral health's impact on colorectal cancer risk, highlighting periodontitis associations.

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Wang et al. (2026) studied this question.

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