Evaluates the role of hydrophobic residues in cellular uptake and localization of cell-penetrating peptides, implying new strategies for enhancing delivery efficiency.
Cell-penetrating peptides (CPPs) are widely used to deliver cargo into mammalian cells, yet efficient cellular uptake and endosomal escape remain key challenges. In this study, we evaluated how hydrophobic (4S)-4-cyclohexylproline...
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Schmitt et al. (2026) studied this question.
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