Key result
Intravenous insulin significantly attenuated pressor responsiveness to phenylephrine (PD25 increased from 38 to 62 mcg, p<0.05) and angiotensin II in diabetic patients without autonomic neuropathy.
Why the study?
Does IV insulin reduce pressor responsiveness to alpha agonists and angiotensin II in diabetic patients without autonomic neuropathy?
Population
15 diabetic patients without autonomic neuropathy
Comparison
Insulin 4 U IV injection vs Saline injection
Design
Other
Authors
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Acute insulin may blunt pressor responses in diabetics without neuropathy; leaves open mechanistic and clinical relevance pending larger studies.
Does IV insulin reduce pressor responsiveness to alpha agonists and angiotensin II in diabetic patients without autonomic neuropathy?
p-value: p=<0.05
Acute administration of IV insulin attenuates pressor responsiveness to phenylephrine and angiotensin II in diabetic patients, suggesting a mechanism for insulin-induced vasodilation.
Yamamoto et al. (1986) studied Diabetes mellitus (n=15). Insulin (Actrapid monocomponent) vs. Saline was evaluated on Pressor responsiveness to phenylephrine (PD25) and angiotensin II (AD30) (p=<0.05). Intravenous insulin significantly attenuated pressor responsiveness to phenylephrine (PD25 increased from 38 to 62 mcg, p<0.05) and angiotensin II in diabetic patients without autonomic neuropathy.
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