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The study aims to investigate the immunohistochemical characteristics and hematological changes in dogs with cutaneous leiomyosarcoma.

May 16, 2026Open Access

Immunohistochemical expression of EGFR, E-Cadherin, β-Catenin, and Ki67 in dogs with local and invasive cutaneous leiomyosarcoma

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Randomized trial evaluates immunohistochemical profiles of cutaneous leiomyosarcoma in dogs, suggesting implications for targeted therapies.

The study aims to investigate the immunohistochemical characteristics and hematological changes in dogs with cutaneous leiomyosarcoma.
Examined six cases of cutaneous leiomyosarcoma over ten years in Urmia, Iran, from a cohort of 318 dogs.
Analyzed immunohistochemical expressions of EGFR, E-Cadherin, β-Catenin, and Ki67 using histological samples.
Conducted hematological analyses to compare affected dogs with healthy controls.
Significant leukocytosis, monocytosis, and eosinophilia observed (p < 0.05).
Increased expression of EGFR and β-Catenin in localized LMS compared to invasive LMS and normal tissues (p < 0.05).
Combined evaluation of E-Cadherin and β-Catenin with proliferation markers may inform invasion pathways.

Heydarzadeh et al. (2025) studied this question.

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Randomized trial evaluates immunohistochemical profiles of cutaneous leiomyosarcoma in dogs, suggesting implications for targeted therapies.